Imprint of Early tRNA Diversification on the Genetic Code
Analysis of the conserved trace of tRNA molecules attributed to the last common ancestor, by phylogenetic techniques adapted to pre-divergence evolution, revealed that the genetic code contains domains of nearest-neighbor base triplets read by tRNA adaptors, descended from a common ancestor, that convey amino acids synthesized from a common precursor. This finding provides compelling evidence that tRNA molecules were cofactors in amino acid synthesis, in the era preceding the last common ancestor. This help make sense of the structure of the genetic code, especially regarding the source of its coding domains.
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