Arthur Conan Doyle was born at Picardy Place, Edinburgh, as the son of Charles Altamont Doyle, a civil servant in the Edinburgh Office of Works, and Mary (Foley) Doyle. Both of Doyle's parents were Roman Catholics. To increase his income Charles Altamont painted, made book illustrations, and also worked as a sketch artist on criminal trials. Not long after arriving Edinburgh he started to drink, he suffered from epilepsy and was eventually institutionalized. Doyle's mother was interested in literature, and she encouraged his son to take to books. Doyle read voluminously. At the age of fourteen he had learned French so that he read Jules Verne in the author's original language. Later Doyle's second wife, Jean, said: "My husband's mother was a very remarkable and highly cultured woman. She had a dominant personality, wrapped up on the most charming womanly exterior." Charles Altamot died in an asylum in 1893; in the same year Doyle decided to finish permanently the adventures of his master detective. Because of financial problems, Doyle's mother kept a boarding house. Dr. Tsukasa Kobayashi has alluded in an article, that Doyle's mother had a long affair with Bryan Charles Waller, a lodger and a student of pathology, who had a deep impact to Conan Doyle.
Doyle was educated in Jesuit schools. During this period Doyle lost his belief in the Roman Catholic faith but the training of the Jesuits influenced deeply his mental development. Later he used his friends and teachers from Stonyhurst College as models for his characters in the Holmes stories, among them two boys named Moriarty. He studied at Edinburgh University and in 1884 he married Louise Hawkins. Doyle qualified as doctor in 1885. After graduation Doyle practiced medicine as an eye specialist at Southsea near Porsmouth in Hampshire until 1891 when he became a full time writer. Doyle had produced his first story, an illustrated tale of a man and a tiger, at the age of six. Doyle's first story about Holmes, A STUDY IN SCARLET, was published in 1887 in Beeton Christmas Annual. The novel was written in three weeks in 1886. It introduced the detective and his Sancho Panza and Boswell, Dr. Watson, the narrator of the stories. Their major opponent was the evil genius Moriarty, the classic villain and a kind of doppelgänger of Holmes. Also the intrigues of the beautiful opera singer Irene Adler caused much trouble to Holmes.
The second Sherlock Holmes story, The Sign of the Four', was written for the Lippincott's Magazine. The story collects a colorful group of people together, among them Jonathan Small who has a wooden leg and a dwarf from Tonga islands. The Strand Magazine started to publish 'The Adventures of Sherlock Holmes' from July 1891. Holmes's address at Mrs. Hudson's house, 221B Baker Street, London, became soon the most famous London street in literature. However, already at the end of 1891, Doyle planned to end the series and in 1893 he became so wearied of his detective that he devised his death in the 'Final Problem,' published in the Strand in the December issue. Holmes meets Moriarty at the fall of the Reichenbach in Switzerland and disappears. Watson finds a letter from Homes, stating "I have already explained to you, however, that my career had in any case reached its crisis, and that no possible conclusion to it could be more congenial to me than this."
Doyle's readers expressed their disappointment by wearing mourning bands and Strand lost 20,000 subscriptions. In THE HOUND OF BASKERVILLES (1902) Doyle narrated an early case of the dead detective. The ingenious murder weapon in the story is an animal. Because of public demand Doyle resurrected his popular hero in 'The Empty House' (1903).