A new disease, space plague, shows itself as a gradual hardening, crystallization of body tissues. The disease is lethal; however, the hardened tissues can be worked up, in order to survive and become a super human. A novel “Highways in Hiding” by George Oliver Smith, a twentieth century American science fiction author, also known by the pseudonym Wesley Long, was published in 1955. Later in 1957 it was abridged as “Space Plague”. The variation of further evolution of humanity, when a completely new “Homo Supuries” appears, is a high quality detective story, involving a confrontation of the old world (usual people and their society) and thw new one (Mekstroms – super people). While a story of a common man, in search of his place in this changing world, lies at the heart of the plot.